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If adrenaline is given with Propranolol, laboratory determinations should be made at regular intervals. Propranolol may increase oxygen requirements by increasing left ventricular fiber length, end diastolic pressure, and the velocity and extent of myocardial contraction. Propranolol is a competitive antagonist which specifically competes with beta-adrenergic receptor stimulating agents for available beta-receptor sites. Propranolol is used to prevent migraine, although it is not fully understood how Propranolol works in this area. Propranolol should be administered with caution since it may block bronchodilation produced by endogenous and exogenous catecholamine stimulation of beta-adrenergic receptors. If you have ischemic heart disease. If Propranolol is taken in combination with other drugs, particularly a thiazide diuretic. Care should be taken if adrenaline is given with Propranolol, laboratory determinations should be made at regular intervals.
