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Mixing trazadone and lexapro: "Lexapro affects chemicals in the brain, is an important factor in the development and severity of depressive symptoms, such as sad mood, fatigue, lack of pleasure, etc. Escitalopram appears to work by increasing the available supply of serotonin, a natural substance in the brain that may become unbalanced and cause depression or anxiety. If left untreated, can cause major problems in your life."